Tg(Vav1-STAT5B*N642H)726Biat
Transgene Detail

Summary

• Symbol: Tg(Vav1-STAT5B*N642H)726Biat
• Name: transgene insertion 726, Biomodels Austria
• MGI ID: MGI:6164037
• Synonyms: Tg(STAT5BN/H)726Biat
• Transgene: Tg(Vav1-STAT5B*N642H)726Biat Location: unknown
• Alliance: Tg(Vav1-STAT5B*N642H)726Biat page

Transgene origin

• Strain of Origin: C57BL/6NCrl

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Vav1-STAT5B*N642H)726Biat expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  STAT5B (6777)

  Stat5b

  (MGI:103035)

• Mutation details: The human STAT5B harboring the N642H mutation in the SH2 domain is under the control of the hematopoietic specific Vav1 promoter. This is a gain-of-function mutation in leukemic patients that causes enhanced and prolonged tyrosine phosphorylation. (J:257519)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:257519 Pham HTT, et al., STAT5BN642H is a driver mutation for T cell neoplasia. J Clin Invest. 2018 Jan 2;128(1):387-401
• All: 4 reference(s)