Tg(Fabp4-LMNA*R482Q)#Hjw
Transgene Detail

Summary

• Symbol: Tg(Fabp4-LMNA*R482Q)#Hjw
• Name: transgene insertion, Howard J Worman
• MGI ID: MGI:6188858
• Transgene: Tg(Fabp4-LMNA*R482Q)#Hjw Location: unknown
• Alliance: Tg(Fabp4-LMNA*R482Q)#Hjw page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Fabp4-LMNA*R482Q)#Hjw expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LMNA (4000)

  Lmna	(MGI:96794)

• Mutation details: This transgene consists of the adipose-specific 5.4-kb fatty acid binding protein 4 promoter, cDNA encoding a FLAG epitope tag fused in frame to the full-length human prelamin A containing a substitution of a basic arginine with a neutral glutamine at amino acid 482 (R482Q), an SV40 splice site and a polyadenylation site. FLAG-tagged proteins are selectively expressed in extracts of adipose tissue but not liver. (J:237920)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:237920 Le Dour C, et al., Extracellular matrix remodeling and transforming growth factor-beta signaling abnormalities induced by lamin A/C variants that cause lipodystrophy. J Lipid Res. 2017 Jan;58(1):151-163
• All: 1 reference(s)