Tg(Myh6-Pkp2*/mRuby)4Rbrug
Transgene Detail

Summary

• Symbol: Tg(Myh6-Pkp2*/mRuby)4Rbrug
• Name: transgene insertion 4, Ramon Brugada
• MGI ID: MGI:6188930
• Synonyms: TG-M
• Transgene: Tg(Myh6-Pkp2*/mRuby)4Rbrug Location: unknown
• Alliance: Tg(Myh6-Pkp2*/mRuby)4Rbrug page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(Myh6-Pkp2*/mRuby)4Rbrug expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Lmna	truncated form

• Mutation details: The alpha-myosin heavy chain promoter drives the expression of a truncated PKP2 which only expresses the first 329 amino acids, fused to the tag proteins T2a and Ruby. The T2a contains an auto-cleaved site which allows Ruby release from the construct. Line 4 is a higher expresser than line 5, with transcript expression roughly doubling that on line 5. (J:237859)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:237859 Moncayo-Arlandi J, et al., Molecular disturbance underlies to arrhythmogenic cardiomyopathy induced by transgene content, age and exercise in a truncated PKP2 mouse model. Hum Mol Genet. 2016 Sep 01;25(17):3676-3688
• All: 1 reference(s)