Tg(Myh6-Prkaca)2Eno
Transgene Detail

Summary

• Symbol: Tg(Myh6-Prkaca)2Eno
• Name: transgene insertion 2, Eric N Olson
• MGI ID: MGI:6193913
• Synonyms: alphaMHC-PKA Tg2
• Transgene: Tg(Myh6-Prkaca)2Eno Location: unknown
• Alliance: Tg(Myh6-Prkaca)2Eno page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Prkaca)2Eno expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Prkaca

• Mutation details: The alpha-MHC promoter drives the expression of the PKA-Calpha cDNA. Overexpression of the catalytic subunit results in constitutive activation of the enzyme without a requirement for cAMP. Assays for activity in heart extracts show that Prkaca activity is elevated 8-fold in line 2. (J:263774)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:263774 Antos CL, et al., Dilated cardiomyopathy and sudden death resulting from constitutive activation of protein kinase a. Circ Res. 2001 Nov 23;89(11):997-1004
• All: 1 reference(s)