Tg(GFAP-ATXN7*92Q)2521Als
Transgene Detail

Summary

• Symbol: Tg(GFAP-ATXN7*92Q)2521Als
• Name: transgene insertion 2521, Albert La Spada
• MGI ID: MGI:6194621
• Synonyms: Gfa2-SCA7-92Q line 2,521
• Transgene: Tg(GFAP-ATXN7*92Q)2521Als Location: unknown
• Alliance: Tg(GFAP-ATXN7*92Q)2521Als page

Transgene origin

• Strain of Origin: (C57BL/6J x C3H/HeJ)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(GFAP-ATXN7*92Q)2521Als expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ATXN7 (6314)

  Atxn7

  (MGI:2179277)

• Mutation details: A 2.2-kb human glial fibrillary acidic protein fragment of the promotor region drives the expression of a flag and c-myc tagged human ataxin-7 cDNA bearing 92 glutamines. Western blot analysis confirmed expression of the transgene. Immunostaining confirmed that expression is restricted to regions of the cerebellum in which Bergmann glia reside and is probably nuclear and cytosolic. This is the moderate expressing line. (J:113150)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:113150 Custer SK, et al., Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport. Nat Neurosci. 2006 Oct;9(10):1302-11
• All: 1 reference(s)