Tg(CAG-Alk*F1174L,-luc)60Jhsc
Transgene Detail

Summary

• Symbol: Tg(CAG-Alk*F1174L,-luc)60Jhsc
• Name: transgene insertion 60, Johannes H Schulte
• MGI ID: MGI:6196043
• Synonyms: ALK^F1174L, LSL-ALK^F1174L
• Transgene: Tg(CAG-Alk*F1174L,-luc)60Jhsc Location: unknown
• Alliance: Tg(CAG-Alk*F1174L,-luc)60Jhsc page

Transgene origin

• Strain of Origin: C57BL/6 or FVB/N

Transgene description

• Transgene Type: Transgenic (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: This transgene consists of the 1.8-kb chicken beta-actin promoter (pCAG), loxP-flanked GFP cassette acting as a STOP cassette, ALK cDNA containing the phenylalanine to leucine mutation at amino acid 1174 (F1174L), IRES, and a fusion construct encoding firefly luciferase and chicken ovalbumin. This line showed the highest luciferase activity upon cre-mediated removal of the GFP. (J:186696)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:186696 Heukamp LC, et al., Targeted expression of mutated ALK induces neuroblastoma in transgenic mice. Sci Transl Med. 2012 Jul 4;4(141):141ra91
• All: 3 reference(s)