Tg(APCS-Tnfsf11*)#aKhs
Transgene Detail

Summary

• Symbol: Tg(APCS-Tnfsf11*)#aKhs
• Name: transgene insertion #a, Kanji Higashio
• MGI ID: MGI:6197466
• Synonyms: SG2-sODF
• Transgene: Tg(APCS-Tnfsf11*)#aKhs Location: unknown
• Alliance: Tg(APCS-Tnfsf11*)#aKhs page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(APCS-Tnfsf11*)#aKhs expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tnfsf11 (MGI:1100089)	expresses a soluble form

• Mutation details: A 1 kb mouse cDNA fragment coding extracellular hydrophilic domain (residues 71-316) is under the control of the human serum amyloid P component promoter, resulting hepatocyte-specific expression of a soluble form. (J:264357)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:264357 Mizuno A, et al., Transgenic mice overexpressing soluble osteoclast differentiation factor (sODF) exhibit severe osteoporosis. J Bone Miner Metab. 2002;20(6):337-44
• All: 1 reference(s)