Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc
Transgene Detail

Summary

• Symbol: Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc
• Name: transgene insertion 1, David C Chan
• MGI ID: MGI:6198713
• Synonyms: Mfn2^T105M, Tg1Mfn2^T105M
• Transgene: Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc Location: unknown Genetic Position: Chr11, Syntenic
• Alliance: Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mfn2 (MGI:2442230)

• Mutation details: The Mnx1 (homeobox HB9) promoter drives the expression of a C-terminally Myc-tagged mouse mitofusin 2 with the T105M mutation found in families with Charcot-Marie-Tooth disease type 2A followed by an IRES and an EGFP in motor neurons. Western blot analysis with an anti-Myc antibody confirmed expression of the transgene. Sequence analysis of the insertion site indicates that the transgene inserted into a non-coding region on chromosome 11 between genes Rad51c and Ppm1e. (J:132035)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:132035 Detmer SA, et al., Hindlimb gait defects due to motor axon loss and reduced distal muscles in a transgenic mouse model of Charcot-Marie-Tooth type 2A. Hum Mol Genet. 2008 Feb 1;17(3):367-75
• All: 1 reference(s)