Tg(H2-K-Hmga1)#Lmsr
Transgene Detail

Summary

• Symbol: Tg(H2-K-Hmga1)#Lmsr
• Name: transgene insertion, Linda MS Resar
• MGI ID: MGI:6231206
• Transgene: Tg(H2-K-Hmga1)#Lmsr Location: unknown
• Alliance: Tg(H2-K-Hmga1)#Lmsr page

Transgene origin

• Strain of Origin: C57BL/6 or SJL

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(H2-K-Hmga1)#Lmsr expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Hmga1 (MGI:96160)

• Mutation details: The murine Hmga1 coding sequence is under the control of the murine H2-K promoter and immunoglobulin mu intronic enhancer which drive expression in B and T cells. Western blot analysis confirmed increased protein levels of Hmga1 in splenocytes. Seven lines were generated and the pound symbol (#) is used because line numbers are not specified although the line with 20 copies of the transgene is used most often. (J:90252)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:90252 Xu Y, et al., The HMG-I oncogene causes highly penetrant, aggressive lymphoid malignancy in transgenic mice and is overexpressed in human leukemia. Cancer Res. 2004 May 15;64(10):3371-5
• All: 6 reference(s)