Tg(tetO-EGFR*)#Kkw
Transgene Detail

Summary

• Symbol: Tg(tetO-EGFR*)#Kkw
• Name: transgene insertion, Kwok-Kin Wong
• MGI ID: MGI:6256806
• Synonyms: EGFR exon 19 Deletion-T790M, EGFR TD
• Transgene: Tg(tetO-EGFR*)#Kkw Location: unknown
• Alliance: Tg(tetO-EGFR*)#Kkw page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-EGFR*)#Kkw expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  EGFR (1956)

  Egfr	(MGI:95294)

  contains T790M and delE746_A750

• Mutation details: Seven direct repeats of the tetracycline operator sequence drive the inducible expression of the human EGFR with the T790M mutation and deletion of exon 19 (del E746_A750). Mice with this transgene that express the tetracycline transactivator (tTA) or reverse transactivator (rtTA) under the control of a tissue-specific promoter can be induced to express the mutant gene in tissues or cell types of interest by administration/withdrawal of doxycycline. (J:156440)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:156440 Zhou W, et al., Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature. 2009 Dec 24;462(7276):1070-4
• All: 4 reference(s)