Tg(RP11-578M14)5Mkru
Transgene Detail

Summary

• Symbol: Tg(RP11-578M14)5Mkru
• Name: transgene insertion 5, M Katharine Rudd
• MGI ID: MGI:6273991
• Synonyms: GNB3, GNB3-T
• Transgene: Tg(RP11-578M14)5Mkru Location: unknown
• Alliance: Tg(RP11-578M14)5Mkru page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(RP11-578M14)5Mkru expresses 12 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CD4 (920)

  Cd4	(MGI:88335)

  human

  CDCA3 (83461)

  Cdca3

  (MGI:1315198)

  human

  COPS7A (50813)

  Cops7a

  (MGI:1349400)

  human

  GNB3 (2784)

  Gnb3	(MGI:95785)

  human

  GPR162 (27239)

  Gpr162

  (MGI:1315214)

  human

  LAG3 (3902)

  Lag3	(MGI:106588)

  human

  MLF2 (8079)

  Mlf2	(MGI:1353554)

  human

  P3H3 (10536)

  P3h3	(MGI:1315208)

  human

  PTMS (5763)

  Ptms	(MGI:1916452)

  human

  SPSB2 (84727)

  Spsb2

  (MGI:1315199)

  human

  TPI1 (7167)

  Tpi1	(MGI:98797)

  human

  USP5 (8078)

  Usp5	(MGI:1347343)

• Mutation details: The transgene consists of BAC RP11-578M14 (184 kb) containing 14 human genes (GNB3, MLF2, CD4, PTMS, LAG3, COPS7A, GPR162, P3H3 (LEPREL2), CDCA3, USP5, TPI1, SPSB2, RPL13P5, and DSTNP2) from 12p13.31, including the T variant of GNB3. Lines 5, 4 and 3 were generated. (J:201055)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:201055 Goldlust IS, et al., Mouse model implicates GNB3 duplication in a childhood obesity syndrome. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14990-4
• All: 2 reference(s)