Tg(Krt14-Rac1*G12V)#Mrnk
Transgene Detail

Summary

• Symbol: Tg(Krt14-Rac1*G12V)#Mrnk
• Name: transgene insertion, M Peter Marinkovich
• MGI ID: MGI:6274278
• Synonyms: RAC^V12
• Transgene: Tg(Krt14-Rac1*G12V)#Mrnk Location: unknown
• Alliance: Tg(Krt14-Rac1*G12V)#Mrnk page

Transgene origin

• Strain of Origin: CBA/CaJ

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Krt14-Rac1*G12V)#Mrnk expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Rac1

• Mutation details: A constitutively active form of Rac1 (RAC1^V12), containing a point mutation C17 to A which results in a glycine to valine substitution at amino acid 12, with a C-terminal c-Myc tag is under the control of the keratin 14 promoter. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:237134)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:237134 Winge MC, et al., RAC1 activation drives pathologic interactions between the epidermis and immune cells. J Clin Invest. 2016 Jul 01;126(7):2661-77
• All: 2 reference(s)