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Tg(Myh6-Kcnj8*/EGFP)1Wco
Transgene Detail
Summary
Symbol: Tg(Myh6-Kcnj8*/EGFP)1Wco
Name: transgene insertion 1, William A Coetzee
MGI ID: MGI:6275008
Synonyms: alpha-MHC-Kir6.1-AAA-eGFP, Kir6.1-AAA
Transgene: Tg(Myh6-Kcnj8*/EGFP)1Wco  Location: unknown  
Alliance: Tg(Myh6-Kcnj8*/EGFP)1Wco page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Dominant negative, Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Tg(Myh6-Kcnj8*/EGFP)1Wco expresses 1 gene
 
Mutation detailsThe alpha-myosin heavy chain promoter drives cardiac-specific expression of a dominant negative rat Kcnj8 mutant, in which the subunit pore region was mutated from glycine-phenylalanine-glycine to three alanines, with a COOH-terminal enhanced green fluorescent protein. RT-PCR and Western blotting confirmed expression of the transgene specifically in the heart. Several lines were made but only one was further analyzed. (J:116284)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:116284 Tong X, et al., Consequences of cardiac myocyte-specific ablation of KATP channels in transgenic mice expressing dominant negative Kir6 subunits. Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H543-51
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory