Tg(Myh6-Kcnj8*/EGFP)1Wco
Transgene Detail
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Symbol: |
Tg(Myh6-Kcnj8*/EGFP)1Wco |
Name: |
transgene insertion 1, William A Coetzee |
MGI ID: |
MGI:6275008 |
Synonyms: |
alpha-MHC-Kir6.1-AAA-eGFP, Kir6.1-AAA |
Transgene: |
Tg(Myh6-Kcnj8*/EGFP)1Wco Location: unknown
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Alliance: |
Tg(Myh6-Kcnj8*/EGFP)1Wco page
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Transgene Type: |
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Transgenic (Dominant negative, Inserted expressed sequence, Reporter) |
Mutation: |
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Insertion
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Tg(Myh6-Kcnj8*/EGFP)1Wco expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
rat |
Kcnj8 (25472) |
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the subunit pore region is mutated to three alanines resulting in a dominant negative |
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Mutation details: The alpha-myosin heavy chain promoter drives cardiac-specific expression of a dominant negative rat Kcnj8 mutant, in which the subunit pore region was mutated from glycine-phenylalanine-glycine to three alanines, with a COOH-terminal enhanced green fluorescent protein. RT-PCR and Western blotting confirmed expression of the transgene specifically in the heart. Several lines were made but only one was further analyzed.
(J:116284)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:116284 Tong X, et al., Consequences of cardiac myocyte-specific ablation of KATP channels in transgenic mice expressing dominant negative Kir6 subunits. Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H543-51 |
All: |
2 reference(s) |
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