Tg(tetO-TGFA)22.1Kor
Transgene Detail

Summary

• Symbol: Tg(tetO-TGFA)22.1Kor
• Name: transgene insertion 22.1, Thomas R Korfhagen
• MGI ID: MGI:6275554
• Synonyms: (TetO)7-cmv TGF-alpha
• Transgene: Tg(tetO-TGFA)22.1Kor Location: unknown
• Alliance: Tg(tetO-TGFA)22.1Kor page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-TGFA)22.1Kor expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TGFA (7039)

  Tgfa	(MGI:98724)

• Mutation details: The transgene is composed of 7 copies of tet operator binding sequence (tetO) linked to a minimal CMV promoter, human TGF-alpha cDNA, and SV40 polyadenylation signal. Two lines, 22.1 and 23.5, were generated. Line 22.1 was used for detailed phenotypic analysis and is entered as the representative line. (J:101255)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cx1	Tg(Scgb1a1-rtTA)1Jaw/0 Tg(tetO-TGFA)22.1Kor/0	involves: 129 * C57BL/6
cx2  Disease Model	Tg(Scgb1a1-rtTA)1Jaw/0 Tg(tetO-TGFA)22.1Kor/0	involves: 129 * C57BL/6 * FVB/NJ

Phenotypes:

Affected Systems	cx1	cx2
show or hide all annotated terms
growth/size/body	√
weight loss	√
homeostasis/metabolism	√	√
increased hydroxyproline level	√	√
respiratory system	√	√
abnormal pulmonary acinus morphology	√
pulmonary fibrosis	√	√
pulmonary interstitial fibrosis		√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	cx2
pulmonary fibrosis IDs pulmonary fibrosis       DOID:3770 MESH:D011658 NCI:C26869 UMLS_CUI:C0034069 Close	√

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:101255 Hardie WD, et al., Conditional expression of transforming growth factor-alpha in adult mouse lung causes pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2004 Apr;286(4):L741-9
• All: 8 reference(s)