Tg(Myh6-Camk2d_ic)LJhb
Transgene Detail

Summary

• Symbol: Tg(Myh6-Camk2d_ic)LJhb
• Name: transgene insertion L, Joan Heller Brown
• MGI ID: MGI:6276041
• Synonyms: TGL
• Transgene: Tg(Myh6-Camk2d_ic)LJhb Location: unknown
• Alliance: Tg(Myh6-Camk2d_ic)LJhb page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Camk2d_ic)LJhb expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Camk2d (24246)

  Camk2d

  (MGI:1341265)

  cytoplasmic isoform

• Mutation details: A hemagglutinin (HA)-tagged rat cDNA for the cytoplasmic variant of Camk2d is under the control of the 5.5-kb murine alpha-MHC promoter. Immunocytochemical staining confirmed that the expressed transgene is expressed only in the heart and is confined in the cytoplasm of cardiomyocytes. Three lines (TGL, TGM, and TGH) were generated. This TGL line carries 3 copies of the transgene and is the low copy number line. Protein levels are increased 12-fold over wild-type levels but the amount of activated Camk2d is only increased 1.7-fold in hearts. (J:130644)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:130644 Zhang T, et al., The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ Res. 2003 May 2;92(8):912-9
• All: 1 reference(s)