Tg(CAG-Ncoa6)87Hwl
Transgene Detail

Summary

• Symbol: Tg(CAG-Ncoa6)87Hwl
• Name: transgene insertion 87, Han-Woong Lee
• MGI ID: MGI:6276321
• Synonyms: DN1
• Transgene: Tg(CAG-Ncoa6)87Hwl Location: unknown
• Alliance: Tg(CAG-Ncoa6)87Hwl page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-Ncoa6)87Hwl expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Ncoa6

• Mutation details: This transgene consists of a hemagglutinin (HA)-tagged fragment of Ncoa6 encoding amino acids 849-929 under the control of the chicken beta-actin promoter linked to a human cytomegalovirus immediate-early enhancer (CAG). This Ncoa6 fragment encompasses the N-terminal LXXLL motif (called DN1) and has a strong dominant negative effect on transactivation by retinoid and other nuclear receptors. This line shows high transgene expression in the eye and heart, and expression in the respiratory tract, liver, thymus, spleen, gall bladder, and kidney. (J:80609)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:80609 Kim SW, et al., Multiple developmental defects derived from impaired recruitment of ASC-2 to nuclear receptors in mice: implication for posterior lenticonus with cataract. Mol Cell Biol. 2002 Dec;22(24):8409-14
• All: 2 reference(s)