Tg(Prnp-MAPT*P301S)50Hiw
Transgene Detail

Summary

• Symbol: Tg(Prnp-MAPT*P301S)50Hiw
• Name: transgene insertion 50, Hiroki Iwashita
• MGI ID: MGI:6286246
• Synonyms: TPR50
• Transgene: Tg(Prnp-MAPT*P301S)50Hiw Location: unknown
• Alliance: Tg(Prnp-MAPT*P301S)50Hiw page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-MAPT*P301S)50Hiw expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

  encodes the longest isoform with the P301S mutation

• Mutation details: The mouse prion promoter drives the expression of the longest human tau (MAPT) isoform (4R2N) in which proline is replaced by a serine at amino acid position 301 of the protein (P301S). Seven lines were established (16, 50, 56, 72, 82, 96, and 100). Line 50 is the highest expressing line. Western blot analysis confirmed increased expression in the hippocampus and showed that human tau is phosphorylated at T181, S202/T205, S214, S262, and S396. (J:213361)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:213361 Onishi T, et al., Early-onset cognitive deficits and axonal transport dysfunction in P301S mutant tau transgenic mice. Neurosci Res. 2014 Mar;80:76-85
• All: 2 reference(s)