Tg(Col1a1-FGF2*,-Sapphire)203Mmh
Transgene Detail

Summary

• Symbol: Tg(Col1a1-FGF2*,-Sapphire)203Mmh
• Name: transgene insertion 203, Marja M Hurley
• MGI ID: MGI:6297004
• Synonyms: TgHMW, TgHMW(203)
• Transgene: Tg(Col1a1-FGF2*,-Sapphire)203Mmh Location: unknown
• Alliance: Tg(Col1a1-FGF2*,-Sapphire)203Mmh page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence, Modified isoform(s), Reporter)
• Mutation: Insertion
• Tg(Col1a1-FGF2*,-Sapphire)203Mmh expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FGF2 (2247)

  Fgf2	(MGI:95516)

  Expresses the high-molecular weight isoforms

• Mutation details: A transgene was designed to contain the human high-molecular weight exported 24-, 23-, and 22-kDa isoforms of FGF2, an internal ribosome entry site (IRES), a blue shifted variant of GFP known as Sapphire under the control of a 3.6 kb fragment of the Col1a1 5 regulatory region (Col3.6). The construct also harbors a neomycin selection cassette. Two lines, 203 and 204 were generated. Line 203 is entered as the representative line. (J:159949)

Disease models

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:159949 Xiao L, et al., Nuclear isoforms of fibroblast growth factor 2 are novel inducers of hypophosphatemia via modulation of FGF23 and KLOTHO. J Biol Chem. 2010 Jan 22;285(4):2834-46
• All: 6 reference(s)