Tg(Itgam-FCAR)83Rcmo
Transgene Detail

Summary

• Symbol: Tg(Itgam-FCAR)83Rcmo
• Name: transgene insertion 83, Renato C Monteiro
• MGI ID: MGI:6313615
• Synonyms: CD89 Tg
• Transgene: Tg(Itgam-FCAR)83Rcmo Location: unknown
• Alliance: Tg(Itgam-FCAR)83Rcmo page

Transgene origin

• Strain of Origin: NOD

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Itgam-FCAR)83Rcmo expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  human	FCAR (2204)

• Tg(Itgam-FCAR)83Rcmo expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Itgam (MGI:96607)

• Mutation details: The human Fc Fragment of IgA Receptor (CD89) a.1 isoform in under the control of the 1.7-kb mouse Itgam (CD11b) promoter that confers high levels of expression on monocyte/macrophages. Three lines, 73, 83, and 96 were generated. The level of transgene expression is about 10-fold higher on macrophages from line 83 than the other two lines. (J:120534)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:120534 Launay P, et al., Fcalpha receptor (CD89) mediates the development of immunoglobulin A (IgA) nephropathy (Berger's disease). Evidence for pathogenic soluble receptor-Iga complexes in patients and CD89 transgenic mice. J Exp Med. 2000 Jun 5;191(11):1999-2009
• All: 7 reference(s)