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Tg(Thy1-APP*Swe*Ind)fAccu
Transgene Detail
Summary
Symbol: Tg(Thy1-APP*Swe*Ind)fAccu
Name: transgene insertion f, A Claudio Cuello
MGI ID: MGI:6324681
Synonyms: McGill-Thy1-APP Tg
Transgene: Tg(Thy1-APP*Swe*Ind)fAccu  Location: unknown  
Alliance: Tg(Thy1-APP*Swe*Ind)fAccu page
Transgene
origin
Strain of Origin:  (C3H x C57BL/6)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Thy1-APP*Swe*Ind)fAccu expresses 1 gene
 
Mutation detailsThe murine thymocyte antigen promotor (Thy1) drives the expression of the human APP (APP-751) cDNA bearing the Swedish double mutation K670N and M671L and the Indiana mutation V717F primarily in pyramidal neurons of the telencephalon and starting postnatally. Transgene copy number as assessed by Southern blotting is estimated to be about 20. Western blot analysis confirmed overexpression of the transgene in the hippocampus and cortex. Mice express on average 2-fold higher levels of amyloid beta42 than of amyloid beta40 in both cortex and hippocampus. (J:251735)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:251735 Ferretti MT, et al., Transgenic mice as a model of pre-clinical Alzheimer's disease. Curr Alzheimer Res. 2011 Feb;8(1):4-23
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory