Tg(tetO-GFP,-APOL1*)#Susz
Transgene Detail

Summary

• Symbol: Tg(tetO-GFP,-APOL1*)#Susz
• Name: transgene insertion, Katalin Susztak
• MGI ID: MGI:6331300
• Synonyms: TRE-APOL1-G2
• Transgene: Tg(tetO-GFP,-APOL1*)#Susz Location: unknown
• Alliance: Tg(tetO-GFP,-APOL1*)#Susz page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence, Reporter)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: The human APOL1 kidney disease risk variant G1, that has a six nucleotide deletion and is able to lyse T. brucei rhodesiense, is under the control of the tetracycline responsive promoter element. The pound (#) sign is used when the line number is not specified or lines are pooled. The gene is only expressed in a tetracycline/doxycycline controllable manner when mice carrying this allele also carry a tTA or rtTA allele. (J:251848)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:251848 Beckerman P, et al., Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice. Nat Med. 2017 Apr;23(4):429-438
• All: 3 reference(s)