Tg(Thy1-APP*)2Tbay
Transgene Detail

Summary

• Symbol: Tg(Thy1-APP*)2Tbay
• Name: transgene insertion 2, Thomas A Bayer
• MGI ID: MGI:6343355
• Synonyms: Tg4-42, Tg(Thy1-Trh/Abeta*)2Tbay
• Transgene: Tg(Thy1-APP*)2Tbay Location: unknown
• Alliance: Tg(Thy1-APP*)2Tbay page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-APP*)2Tbay expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

  Human APP expressing a truncated (aa 4-42) protein

• Mutation details: The 7.2kb kb Tg4-42 transgene is designed with the Thy1 promoter driving expression of human Abeta 4-42 fused to a murine thyrotropin releasing hormone signal peptide. Transgenic mice express an N-truncated Abeta 4-42< (amino acids 4-42), a peptide shown to enhance Abeta aggregation in the brains of Alzheimer's disease (AD) patients. Founder line 2 has the highest expression of the transgene and sontains more than 20 copies in head-to-tail orientation, with the last transgene in reverse orientation. (J:275188)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:275188 Bouter Y, et al., N-truncated amyloid beta (Abeta) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits. Acta Neuropathol. 2013 Aug;126(2):189-205
• All: 13 reference(s)