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Del(4Sdr16c5-Sdr16c6)1Nyk Cytogenetic Marker Detail
Summary
  • Symbol
    Del(4Sdr16c5-Sdr16c6)1Nyk
  • Name
    deletion, Chr 4, Natalia Y Kedishvili 1
  • Feature Type
    chromosomal deletion
  • IDs
    MGI:6400365
Location &
Maps
less
  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • Genetic Map
    Chromosome 4, Syntenic
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a deletion of Sdr16c5 and Sdr16c6 exhibit accelerated hair growth enlarged meibomian glands.
References
more
  • Summaries
    All 2
    Phenotypes 2
  • Earliest
    J:283063 Wu L, et al., Mice lacking the epidermal retinol dehydrogenases SDR16C5 and SDR16C6 display accelerated hair growth and enlarged meibomian glands. J Biol Chem. 2019 Nov 8;294(45):17060-17074
  • Latest
    J:340060 Butovich IA, et al., Sdr16c5 and Sdr16c6 control a dormant pathway at a bifurcation point between meibogenesis and sebogenesis. J Biol Chem. 2023 Apr 17;299(6):104725
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory