Tg(KRT18-DPP4)3Pbmj
Transgene Detail

Summary

• Symbol: Tg(KRT18-DPP4)3Pbmj
• Name: transgene insertion 3, Paul B McCray Jr
• MGI ID: MGI:6402178
• Synonyms: K18-hDPP4
• Transgene: Tg(KRT18-DPP4)3Pbmj Location: unknown
• Alliance: Tg(KRT18-DPP4)3Pbmj page

Transgene origin

• Strain of Origin: C57BL/6J x SJL/J

Transgene description

• Transgene Type: Transgenic (Epitope tag, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT18-DPP4)3Pbmj expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DPP4 (1803)

  Dpp4	(MGI:94919)

• Mutation details: A FLAG epitope-tagged human DPP4 cDNA is under the control of the human cytokeratin 18 promoter. The promoter directs expression of the Middle East respiratory coronavirus receptor in airway and alveolar epithelial cells, as well as epithelial of the liver, kidney, and gastrointestinal tract, and some nervous system cells. Four lines were generated. (J:285467)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:285467 Li K, et al., Middle East Respiratory Syndrome Coronavirus Causes Multiple Organ Damage and Lethal Disease in Mice Transgenic for Human Dipeptidyl Peptidase 4. J Infect Dis. 2016 Mar 1;213(5):712-22
• All: 7 reference(s)