Tg(FOXJ1-ACE2)1Rba
Transgene Detail

Summary

• Symbol: Tg(FOXJ1-ACE2)1Rba
• Name: transgene insertion 1, Ralph Baric
• MGI ID: MGI:6415223
• Synonyms: HFH4-ACE2, HFH4-hACE2
• Transgene: Tg(FOXJ1-ACE2)1Rba Location: unknown
• Alliance: Tg(FOXJ1-ACE2)1Rba page

Transgene origin

• Strain of Origin: (C3H x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(FOXJ1-ACE2)1Rba expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ACE2 (59272)

  Ace2	(MGI:1917258)

• Mutation details: Human angiotensin-converting enzyme-2 (ACE2) in is expressed under the control of human FOXJ1 gene. Expression was observed in the lungs, and other tissues including brain, liver, kidney, and gastrointestinal tract. (J:287092)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:287092 Menachery VD, et al., SARS-like WIV1-CoV poised for human emergence. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3048-53
• All: 17 reference(s)