Tg(Prnp-Tardbp,-EGFP)19Zxu
Transgene Detail
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Symbol: |
Tg(Prnp-Tardbp,-EGFP)19Zxu |
Name: |
transgene insertion 19, Zuoshang Xu |
MGI ID: |
MGI:6469530 |
Synonyms: |
PrP-TDP43-IRES-EGFP, TDP-43 |
Transgene: |
Tg(Prnp-Tardbp,-EGFP)19Zxu Location: unknown
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Alliance: |
Tg(Prnp-Tardbp,-EGFP)19Zxu page
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Transgene Type: |
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Transgenic (Inserted expressed sequence, Reporter) |
Mutation: |
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Insertion
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Mutation details: A loxP site, mouse Tardbp DNA binding protein cDNA sequence, an internal ribosome entry site (IRES), an enhanced green fluorescent protein sequence (EGFP), a second loxP site and polyA sequence was inserted between exon 2 and exon 3 of mouse Prnp gene. Founder line 19 was identified with GFP expression in central nervous system and desirable Tardbp expression level/pattern.
(J:319624)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:319624 Yang C, et al., Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice. PLoS One. 2022;17(2):e0255710 |
All: |
1 reference(s) |
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