Tg(Thy1-FUS*)1Dit
Transgene Detail

Summary

• Symbol: Tg(Thy1-FUS*)1Dit
• Name: transgene insertion 1, Daisuke Ito
• MGI ID: MGI:6476958
• Synonyms: deltaNLS-FUS, Tg(Thy1-FUS^*deltaNLS)1Dit
• Transgene: Tg(Thy1-FUS*)1Dit Location: unknown
• Alliance: Tg(Thy1-FUS*)1Dit page

Transgene origin

• Strain of Origin: (C57BL/6J x DBA/2J)F1

Transgene description

• Transgene Type: Transgenic (Epitope tag, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-FUS*)1Dit expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FUS (2521)

  Fus	(MGI:1353633)

  lacking the nuclear localization signal sequence

• Mutation details: The transgene contains the 8.1 kb murine Thy1.2 promoter driving expression of human FUS lacking the nuclear-localization sequence with a 5' 3xMyc epitope tag. Line 1 was generated. (J:287782)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:287782 Shiihashi G, et al., Mislocated FUS is sufficient for gain-of-toxic-function amyotrophic lateral sclerosis phenotypes in mice. Brain. 2016 Sep;139(Pt 9):2380-94
• All: 3 reference(s)