Rr95 Other Genome Feature Detail

Summary

• Symbol
  Rr95
• Name
  regulatory region 95
• Synonyms
  Cd4 maturation enhancer, E4m

• Feature Type
  enhancer
• IDs
  MGI:6833885
• Regulates expression of
  Cd4 (1 regulated gene)

Location &
Maps

• Sequence Map
  Chr6:124862196-124862560 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI
• J:267930: chr6:124835251-124835615 (NCBIm37) chr6:124862196-124862560 (GRCm39)

• Genetic Map
  Chromosome 6, Syntenic

Strain
Comparison

• SNPs within 2kb
  82 from dbSNP Build 142

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  2 phenotype references
  

• All Mutations and Alleles
  3
• Endonuclease-mediated
  1
• Targeted
  2
• Find Mice (IMSR)
  0 strains or lines available

Homozygous deletion of this Cd4 T cell maturation enhancer affects commitment and maturation of helper and regulatory T cells.

References

• Summaries
  All 3

  Phenotypes 2
• Earliest
  J:267930 Kojo S, et al., Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene. Nat Commun. 2018 Sep 5;9(1):3593
• Latest
  J:333574 Teghanemt A, et al., CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element. Nat Commun. 2022 Mar 18;13(1):1477

Rr95 regulates expression of:

Feature	Feature Type	Location	Reference
Cd4, CD4 antigen	protein coding gene	Chr6:124841655-124865184 (-)	J:267930