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Rr170 Other Genome Feature Detail
Summary
  • Symbol
    Rr170
  • Name
    regulatory region 170
  • Synonyms
    CNS-1, CNS1, GRE1, GRE2
  • Feature Type
    enhancer
  • IDs
    MGI:6861862
Location &
Maps
more
  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • CNS-1 sequence in J:100878: left edge: TCTTTGCCTGCTTTCGGCTTCAAAGGATCCTACGTTAAGAAACAGAGT; right edge: GATAGCCCATGAAAGGCTGATGAGGTTGGGGTTAGTAGATATAATACATATGAATTTCT: chr15:9533370-9533783 (GRCm39).
  • Genetic Map
    Chromosome 15, Syntenic
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous deletion of this Il7r enhancer reduces T cell survival and proliferation.
References
more
  • Summaries
    All 4
    Phenotypes 2
  • Earliest
    J:100878 Lee HC, et al., Transcriptional regulation of the mouse IL-7 receptor alpha promoter by glucocorticoid receptor. J Immunol. 2005 Jun 15;174(12):7800-6
  • Latest
    J:260412 Shimba A, et al., Glucocorticoids Drive Diurnal Oscillations in T Cell Distribution and Responses by Inducing Interleukin-7 Receptor and CXCR4. Immunity. 2018 Feb 20;48(2):286-298.e6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory