About   Help   FAQ
Rr170 Other Genome Feature Detail
Summary
  • Symbol
    Rr170
  • Name
    regulatory region 170
  • Synonyms
    CNS-1, CNS1, GRE1, GRE2
  • Feature Type
    enhancer
  • IDs
    MGI:6861862
Location &
Maps
more
  • Sequence Map
    Chr15:9533370-9533783 bp
    From MGI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • CNS-1 sequence in J:100878: left edge: TCTTTGCCTGCTTTCGGCTTCAAAGGATCCTACGTTAAGAAACAGAGT; right edge: GATAGCCCATGAAAGGCTGATGAGGTTGGGGTTAGTAGATATAATACATATGAATTTCT: chr15:9533370-9533783 (GRCm39).
  • Genetic Map
    Chromosome 15, Syntenic
Strain
Comparison
more
  • SNPs within 2kb
    107 from dbSNP Build 142
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous deletion of this Il7r enhancer reduces T cell survival and proliferation.
References
more
  • Summaries
    All 4
    Phenotypes 2
  • Earliest
    J:100878 Lee HC, et al., Transcriptional regulation of the mouse IL-7 receptor alpha promoter by glucocorticoid receptor. J Immunol. 2005 Jun 15;174(12):7800-6
  • Latest
    J:260412 Shimba A, et al., Glucocorticoids Drive Diurnal Oscillations in T Cell Distribution and Responses by Inducing Interleukin-7 Receptor and CXCR4. Immunity. 2018 Feb 20;48(2):286-298.e6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory