Rr172 Other Genome Feature Detail

Summary

• Symbol
  Rr172
• Name
  regulatory region 172
• Synonyms
  AICE, Irf8 +32

• Feature Type
  enhancer
• IDs
  MGI:6863877

Location &
Maps

• Sequence Map
  Chr8:121495079-121495626 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI
• J:279982 Fig.S1e coordinates Chr8:120768340-120768887 (GRCm38 according to alignment of sequence: left edge:GTGTTCCTGGGCTGTGGTCATTCCTATTGTATTTGTCTATA; right edge: CTGGTTTCAGGATCGCACCTCACCTACTGGGTGAG): chr8:121495079-121495626 (GRCm39).

• Genetic Map
  Chromosome 8, Syntenic

Strain
Comparison

• SNPs within 2kb
  122 from dbSNP Build 142

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  6 phenotypes from multigenic genotypes
  11 phenotype references
  

• All Mutations and Alleles
  1
• Endonuclease-mediated
  1
• Find Mice (IMSR)
  0 strains or lines available

References

• Summaries
  All 13

  Phenotypes 11
• Earliest
  J:279982 Durai V, et al., Cryptic activation of an Irf8 enhancer governs cDC1 fate specification. Nat Immunol. 2019 Sep;20(9):1161-1173
• Latest
  J:355425 Liu TT, et al., Cis interactions in the Irf8 locus regulate stage-dependent enhancer activation. Genes Dev. 2023 Apr 1;37(7-8):291-302