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Sorbs3 Gene Detail
Summary
  • Symbol
    Sorbs3
  • Name
    sorbin and SH3 domain containing 3
  • Synonyms
    Sh3d4, SH3P3, vinexin alpha, vinexin beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:700013
    NCBI Gene: 20410
  • Alliance
    gene page
  • Transcription Start Sites
    34 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:70417917-70449438 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 36.27 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    781 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_700013
 protein coding gene Chr14:70417917-70449472 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021533
 protein coding gene Chr14:64806498-64834575 (-)
A/J MGP_AJ_G0021492
 protein coding gene Chr14:63444385-63471466 (-)
AKR/J MGP_AKRJ_G0021468
 protein coding gene Chr14:65347125-65375672 (-)
BALB/cJ MGP_BALBcJ_G0021498
 protein coding gene Chr14:63208834-63236251 (-)
C3H/HeJ MGP_C3HHeJ_G0021275
 protein coding gene Chr14:65057155-65085680 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021937
 protein coding gene Chr14:67721947-67750631 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019477
 protein coding gene Chr14:61280589-61308314 (-)
CAST/EiJ MGP_CASTEiJ_G0020792
 protein coding gene Chr14:61640560-61671193 (-)
CBA/J MGP_CBAJ_G0021242
 protein coding gene Chr14:69839589-69869156 (-)
DBA/2J MGP_DBA2J_G0021365
 protein coding gene Chr14:62826736-62854322 (-)
FVB/NJ MGP_FVBNJ_G0021344
 protein coding gene Chr14:62254049-62282074 (-)
LP/J MGP_LPJ_G0021436
 protein coding gene Chr14:66059156-66086207 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021373
 protein coding gene Chr14:68752310-68781412 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021961
 protein coding gene Chr14:64609703-64636831 (-)
PWK/PhJ MGP_PWKPhJ_G0020536
 protein coding gene Chr14:59588867-59616248 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020369
 protein coding gene Chr14:60536950-60566666 (-)
WSB/EiJ MGP_WSBEiJ_G0020845
 protein coding gene Chr14:64913282-64943648 (-)



Homology
more
  • Human Ortholog
    SORBS3, sorbin and SH3 domain containing 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SORBS3, sorbin and SH3 domain containing 3
  • Synonyms
    SCAM-1, SCAM1, SH3D4
  • Links
    NCBI Gene ID: 10174
    neXtProt AC: NX_O60504
    UniProt: O60504

  • Chr Location
    8p21.3; chr8:22544973-22575788 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants are generally normal, viable, and fertile, except showing delayed wound healing in response to full-thickness skin injury in vivo.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    739
  • Tissues
    22
  • cDNA Data
    37
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022091 Ensembl Gene Model | MGI Sequence Detail 31522 C57BL/6J ±  kb
transcript ENSMUST00000022682 Ensembl | MGI Sequence Detail 2914 Not Applicable  
polypeptide ENSMUSP00000022682 Ensembl | MGI Sequence Detail 733 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 38
    cDNA 37
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 41
    Developmental Gene Expression 6
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:35786 Sparks AB, et al., Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins. Nat Biotechnol. 1996 Jun;14(6):741-4
  • Latest
    J:347609 Chen R, et al., Vinexin beta deficiency exacerbates diet-induced obesity, hepatosteatosis, insulin resistance and endoplasmic reticulum stress in mice. Biochem Biophys Res Commun. 2022 Mar 12;596:14-21
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory