Rr124128 Other Genome Feature Detail

Summary

• Symbol
  Rr124128
• Name
  regulatory region 124128
• Synonyms
  ENSMUSR00000216045, Haster

• Feature Type
  promoter
• IDs
  MGI:7012350
• Regulates expression of
  Hnf1a, Hnf1aos1, Hnf1aos2 (3 regulated genes)

Location &
Maps

• Sequence Map
  Chr5:115106000-115110601 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 5, Syntenic
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  187 from dbSNP Build 142

Human Diseases

• Diseases
  1 with Rr124128 mouse models

Human Disease

Mouse Models

diabetes mellitus

IDs

diabetes mellitus      

DOID:9351
ICD10CM:E08-E13
ICD9CM:250
MESH:D003920
NCI:C2985
UMLS_CUI:C0011849

View 2 models

Mouse Models

Human Disease Modeled: diabetes mellitus

Allelic Composition	Genetic Background	Reference	Phenotypes
Rr124128tm1.2Jfer/Rr124128tm1.2Jfer	involves: C57BL/6 * FVB/N	J:332319	View
Rr124128tm1.1Jfer/Rr124128tm1.1Jfer Tg(Pdx1-cre)6Tuv/0	involves: C57BL/6 * FVB/N	J:332319	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  2 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  5 phenotypes from 2 alleles in 1 genetic background
  2 phenotype references
  

• All Mutations and Alleles
  2
• Targeted
  2
• Find Mice (IMSR)
  0 strains or lines available

References

• Summaries
  All 3

  Diseases 1

  Phenotypes 2
• Earliest
  J:332319 Beucher A, et al., The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A. Nat Cell Biol. 2022 Oct;24(10):1528-1540
• Latest
  J:339976 Braun T, et al., Mucosal transcriptomics highlight lncRNAs implicated in ulcerative colitis, Crohn's disease, and celiac disease. JCI Insight. 2023 Jul 24;8(14)

Rr124128 regulates expression of:

Feature	Feature Type	Location	Reference
Hnf1a, HNF1 homeobox A	protein coding gene	Chr5:115087039-115109121 (-)	J:332319
Hnf1aos1, HNF1 homeobox A, opposite strand 1	antisense lncRNA gene	Chr5:115106802-115135985 (+)	J:332319
Hnf1aos2, HNF1 homeobox A, opposite strand 2	antisense lncRNA gene	Chr5:115106882-115109459 (+)	J:332319