Rr149356 Other Genome Feature Detail

Summary

• Symbol
  Rr149356
• Name
  regulatory region 149356
• Synonyms
  Ebeta, Tcrbe

• Feature Type
  enhancer
• IDs
  MGI:7037578
  NCBI Gene: 107711

Location &
Maps

• Sequence Map
  Chr6:41526801-41532817 bp, . strand

  From Ensembl Reg annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 6, Syntenic
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  291 from dbSNP Build 142

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  16 phenotypes from 3 alleles in 3 genetic backgrounds
  4 phenotypes from multigenic genotypes
  20 phenotype references
  

• All Mutations and Alleles
  5
• Targeted
  5
• Find Mice (IMSR)
  0 strains or lines available

Homozygous inactivation of this locus causes arrest of T cell development at the double-negative (DN) cell stage and leads to thymus hypoplasia, increased DN T cell number, decreased double-positive T cell number, decreased single-positive T cell number,and increased gamma-delta T cell number.

Sequences &
Gene Models

• All Sequences
  1

• NCBI Gene
  107711

Representative Sequences			Length	Strain/Species
genomic	ENSMUSR00000226222	Ensembl | MGI Sequence Detail	6017	Not Applicable

Other Database
Links

Ensembl Regulatory Feature

ENSMUSR00000226222

Other
Accession IDs

MGI:892967

References

• Summaries
  All 24

  Phenotypes 20
• Earliest
  J:34311 Bouvier G, et al., Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development. Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7877-81
• Latest
  J:321896 Bonelt P, et al., Precocious expression of Blimp1 in B cells causes autoimmune disease with increased self-reactive plasma cells. EMBO J. 2019 Jan 15;38(2):e100010