Rr250409 Other Genome Feature Detail

Summary

• Symbol
  Rr250409
• Name
  regulatory region 250409
• Synonyms
  Cigs1, CNS-1, HSS1, HSS2

• Feature Type
  enhancer
• IDs
  MGI:7138631

Location &
Maps

• Sequence Map
  Chr11:53517402-53519171 bp, . strand

  From Ensembl Reg annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI
• J:66158 Fig2a: left GAGGCCTCATTATCTTCATTCATTTCTCGGCTCCACCCAAAA chr11:53517951-53517992 (GRCm39) right GCATTGCTCTTCCTGCAGCCCTTGTGCGGCAGCAGCCCTCA chr11:53517587-53517627 J:349483 FigS4B deletion: GCTGTGGACCCCTAGTGGTGAGACTTGGAATGGCTCCATATGCATCTTGTAGAGTGAAGGCTCCTTTTGGAA chr11:53518901-53518972 (GRCm39)

• Genetic Map
  Chromosome 11, Syntenic
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  133 from dbSNP Build 142

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  6 phenotypes from 1 allele in 2 genetic backgrounds
  4 phenotype references
  

• All Mutations and Alleles
  2
• Endonuclease-mediated
  1
• Targeted
  1
• Find Mice (IMSR)
  0 strains or lines available

Mice homozygous for a null allele exhibit reduced interleukin production and IgE serum levels when stimulated under TH2 conditions.

Sequences &
Gene Models

• All Sequences
  1

Representative Sequences			Length	Strain/Species
genomic	ENSMUSR00000042608	Ensembl | MGI Sequence Detail	1770	Not Applicable

Other Database
Links

Ensembl Regulatory Feature

ENSMUSR00000042608

References

• Summaries
  All 8

  Phenotypes 4
• Earliest
  J:61463 Loots GG, et al., Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons [see comments]. Science. 2000 Apr 7;288(5463):136-40
• Latest
  J:349483 Liu S, et al., Regulation of T helper cell differentiation by the interplay between histone modification and chromatin interaction. Immunity. 2024 Apr 5;