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Tg(KRT18*R89C)22Rgo
Transgene Detail
Summary
Symbol: Tg(KRT18*R89C)22Rgo
Name: transgene insertion 22, Robert G Oshima
MGI ID: MGI:7262689
Transgene: Tg(KRT18*R89C)22Rgo  Location: unknown  
Alliance: Tg(KRT18*R89C)22Rgo page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Dominant negative, Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(KRT18*R89C)22Rgo expresses 1 gene
 
Mutation detailsThis transgene consists of the human keratin 18 cDNA containing an arginine to cysteine substitution at amino acid 89 in exon 1. Three lines were generated; F22, F30, and F50. The transgene copy number for line F22 is 10. The relative protein ratio of endogenous mouse Krt18 to over-expressed human KRT18 is 1:2. (J:241700)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:241700 Ku NO, et al., Chronic hepatitis, hepatocyte fragility, and increased soluble phosphoglycokeratins in transgenic mice expressing a keratin 18 conserved arginine mutant. J Cell Biol. 1995 Dec;131(5):1303-14
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory