Tg(KRT18*R89C)30Rgo
Transgene Detail
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Symbol: |
Tg(KRT18*R89C)30Rgo |
Name: |
transgene insertion 30, Robert G Oshima |
MGI ID: |
MGI:7262690 |
Transgene: |
Tg(KRT18*R89C)30Rgo Location: unknown
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Alliance: |
Tg(KRT18*R89C)30Rgo page
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Transgene Type: |
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Transgenic (Dominant negative, Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(KRT18*R89C)30Rgo expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
KRT18 (3875) |
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Mutation details: This transgene consists of the human keratin 18 cDNA containing an arginine to cysteine substitution at amino acid 89 in exon 1. Three lines were generated; F22, F30, and F50. The transgene copy number for line F30 is 12.
(J:241700)
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | involves: FVB/N | |
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Phenotypes: |
Affected Systems |
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cardiovascular system
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abnormal liver vasculature morphology
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liver hemorrhage
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homeostasis/metabolism
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increased circulating alanine transaminase level
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increased circulating aspartate transaminase level
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immune system
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chronic liver inflammation
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liver/biliary system
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abnormal liver vasculature morphology
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liver hemorrhage
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chronic liver inflammation
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abnormal hepatocyte morphology
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hepatic necrosis
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View phenotypes and curated references for all genotypes (concatenated display).
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Key: |
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disease model |
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![](https://www.informatics.jax.org/webshare/images/notSymbol.gif) |
expected model not found |
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Models:
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Human Diseases |
IDs
hepatitis
DOID:2237
DOID:12352
DOID:14551
DOID:1706
DOID:1707
DOID:2238
ICD10CM:K73.9
ICD9CM:570
ICD9CM:571.4
ICD9CM:571.40
ICD9CM:571.41
MESH:D006521
NCI:C82978
UMLS_CUI:C0001308
UMLS_CUI:C0019189
UMLS_CUI:C0149519
Close
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:241700 Ku NO, et al., Chronic hepatitis, hepatocyte fragility, and increased soluble phosphoglycokeratins in transgenic mice expressing a keratin 18 conserved arginine mutant. J Cell Biol. 1995 Dec;131(5):1303-14 |
All: |
1 reference(s) |
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