Thcir2 QTL Detail

Summary

• Symbol
  Thcir2
• Name
  THC initial response 2, hypothermia, males only

• Feature Type
  QTL
• IDs
  MGI:7284969
• Candidate Genes
  1 Gene

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 11, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  2 experiments

References

• Summaries
  All 1
• Earliest
  J:314541 Parks C, et al., Genetic Modulation of Initial Sensitivity to Delta9-Tetrahydrocannabinol (THC) Among the BXD Family of Mice. Front Genet. 2021;12:659012

Candidate Genes for Thcir2:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Rps6kb1	Chr11:86389697-86435631 (-)	J:314541	Top positional candidate genes include: Ndufs2 (MGI:2385112) for Thcir5; Scp2 (MGI:98254) for Thcir6; Rps6kb1 (MGI:1270849) for Thcir2; Pde4d (MGI:99555) for Thcir4; and Pten (MGI:109583) for Thcir3. These genes are likely to play a role in modulating initial response to THC based on location within modulatory QTL, putative functional sequence variants between B and D haplotypes that segregate among BXD progeny, evidence of genetic control of expression in brain tissue, and previously reported involvement in endocannabinoid/cannabinoid receptor signaling pathways.