Gdfsc1 QTL Detail

Summary

• Symbol
  Gdfsc1
• Name
  DF11 serum concentration 1

• Feature Type
  QTL
• IDs
  MGI:7286090
• Candidate Genes
  2 Genes

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 3, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  2 experiments

References

• Summaries
  All 1
• Earliest
  J:313290 Starcher AE, et al., A systems approach using Diversity Outbred mice distinguishes the cardiovascular effects and genetics of circulating GDF11 from those of its homolog, myostatin. G3 (Bethesda). 2021 Sep 2;

Candidate Genes for Gdfsc1:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Foxo1	Chr3:52175758-52257530 (+)	J:313290	QTL Gdfsc1 (GDF11 serum concentration 1) maps to Chr 3: 3.039589 - 9.983782 Mb in close proximity to the gene Hey1, a transcriptional repressor. Bioinformatic analyses located putative binding sites for the HEY1 protein upstream of the Gdf11 gene in the mouse and human genomes. While these findings indirectly support Hey1 as a candidate gene behind circulating GDF11 levels, the authors also cannot exclude other plausible genes within the same locus, such as Stathmin-2 (Stmn2). Stmn2 is another reasonable candidate as it is expressed in both murine and human heart tissue throughout development and into adulthood (Asp et al. 2019; Bult et al. 2019; Smith et al. 2019). QTL Smc1 (serum myostatin concentration 1) maps to Chr 3: 52.26269 - 52.71985 Mb. The peak is located in close proximity to protein-coding gene Forkhead Box O1 (Foxo1; MGI:1890077).
Hey1	Chr3:8728419-8732098 (-)	J:313290	QTL Gdfsc1 (GDF11 serum concentration 1) maps to Chr 3: 3.039589 - 9.983782 Mb in close proximity to the gene Hey1, a transcriptional repressor. Bioinformatic analyses located putative binding sites for the HEY1 protein upstream of the Gdf11 gene in the mouse and human genomes. While these findings indirectly support Hey1 as a candidate gene behind circulating GDF11 levels, the authors also cannot exclude other plausible genes within the same locus, such as Stathmin-2 (Stmn2). Stmn2 is another reasonable candidate as it is expressed in both murine and human heart tissue throughout development and into adulthood (Asp et al. 2019; Bult et al. 2019; Smith et al. 2019). QTL Smc1 (serum myostatin concentration 1) maps to Chr 3: 52.26269 - 52.71985 Mb. The peak is located in close proximity to protein-coding gene Forkhead Box O1 (Foxo1; MGI:1890077).