Tpgi1 QTL Detail

Summary

• Symbol
  Tpgi1
• Name
  Toxoplasma gondii immunity 1, secondary infection survival

• Feature Type
  QTL
• IDs
  MGI:7314933
• Candidate Genes
  1 Gene

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 7, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  2 experiments

References

• Summaries
  All 1
• Earliest
  J:316317 Souza SP, et al., Genetic mapping reveals Nfkbid as a central regulator of humoral immunity to Toxoplasma gondii. PLoS Pathog. 2021 Dec;17(12):e1010081

Candidate Genes for Tpgi1:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Nfkbid	Chr7:30121157-30128171 (+)	J:316317	Nfkbid (MGI:3041243) is one of the most polymorphic genes within the Tpgi1 QTL region and sits between the genetic markers that flank the highest imputed LOD score. The authors explore Nfkbid at length and find strong support for its role in Toxoplasma gondii immunity.