Tg(Zfhx2*R1907K)#Jcox
Transgene Detail

Summary

• Symbol: Tg(Zfhx2*R1907K)#Jcox
• Name: transgene insertion, James J Cox
• MGI ID: MGI:7329776
• Transgene: Tg(Zfhx2*R1907K)#Jcox Location: unknown
• Alliance: Tg(Zfhx2*R1907K)#Jcox page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Zfhx2*R1907K)#Jcox expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Zfhx2 (MGI:2686934)	Contains p.R1907K mutation corresponding to the human p.R1913K mutation.

• Mutation details: BAC clone RP23-248M20 containing the mouse Zfhx2 was modified to contain an arginine to lysine substitution at amino acid 1907 (AGG to AAG). This corresponds to the human p.R1913K mutation identified in a family with Marsili syndrome. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:266472)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:266472 Habib AM, et al., A novel human pain insensitivity disorder caused by a point mutation in ZFHX2. Brain. 2018 Feb 1;141(2):365-376
• All: 1 reference(s)