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Rr253 Other Genome Feature Detail
Summary
  • Symbol
    Rr253
  • Name
    regulatory region 253
  • Synonyms
    Zeb2 -165 kb
  • Feature Type
    enhancer
  • IDs
    MGI:7331605
Location &
Maps
more
  • Sequence Map
    Chr2:45169490-45169853 bp
    From MGI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • chr2:45169490-45169853 deletion in Rr253
  • Genetic Map
    Chromosome 2, Syntenic
Strain
Comparison
more
  • SNPs within 2kb
    78 from dbSNP Build 142
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 5 alleles in 5 genetic backgrounds
    7 phenotypes from multigenic genotypes
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Deletion of this Zeb2 enhancer affects the ratio of immunological cell types in the spleen and increases susceptibility to viral infection.
References
more
  • Summaries
    All 4
    Phenotypes 3
  • Earliest
    J:316113 Huang X, et al., Differential usage of transcriptional repressor Zeb2 enhancers distinguishes adult and embryonic hematopoiesis. Immunity. 2021 Jul 13;54(7):1417-1432.e7
  • Latest
    J:343149 Kim S, et al., IL-6 selectively suppresses cDC1 specification via C/EBPbeta. J Exp Med. 2023 Oct 2;220(10)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory