Rr266 Other Genome Feature Detail

Summary

• Symbol
  Rr266
• Name
  regulatory region 266
• Synonyms
  Ins1 GG2-GG1/A2-C1

• Feature Type
  enhancer
• IDs
  MGI:7338988

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.
• chr19:52252736-52252768

• Genetic Map
  Chromosome 19, Syntenic

Human Diseases

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  4 phenotypes from multigenic genotypes
  1 phenotype reference
  

• All Mutations and Alleles
  4
• Endonuclease-mediated
  4
• Find Mice (IMSR)
  0 strains or lines available

Deletion of this Ins1 promoter enhancer element together with the paralogous Ins2 element causes diabetes.

References

• Summaries
  All 2

  Diseases 1

  Phenotypes 1
• Earliest
  J:312429 Noguchi H, et al., In vivo evaluation of GG2-GG1/A2 element activity in the insulin promoter region using the CRISPR-Cas9 system. Sci Rep. 2021 Oct 13;11(1):20290