Rr268 Other Genome Feature Detail

Summary

• Symbol
  Rr268
• Name
  regulatory region 268
• Synonyms
  Ins2 GG2-GG1/A2-C1

• Feature Type
  enhancer
• IDs
  MGI:7338990

Location &
Maps

• Sequence Map
  Chr7:142233564-142233596 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI
• chr19:142233564-142233596 (GRCm39)

• Genetic Map
  Chromosome 7, Syntenic

Strain
Comparison

• SNPs within 2kb
  65 from dbSNP Build 142

Human Diseases

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  4 phenotypes from multigenic genotypes
  1 phenotype reference
  

• All Mutations and Alleles
  5
• Endonuclease-mediated
  5
• Find Mice (IMSR)
  0 strains or lines available

Deletion of this Ins2 promoter enhancer element together with the paralogous Ins1 element causes diabetes.

References

• Summaries
  All 2

  Diseases 1

  Phenotypes 1
• Earliest
  J:312429 Noguchi H, et al., In vivo evaluation of GG2-GG1/A2 element activity in the insulin promoter region using the CRISPR-Cas9 system. Sci Rep. 2021 Oct 13;11(1):20290