Rr272 Other Genome Feature Detail

Summary

• Symbol
  Rr272
• Name
  regulatory region 272
• Synonyms
  Vsx2 CRC-SE, Vsx2-SE

• Feature Type
  enhancer
• IDs
  MGI:7339259
• Cluster Members
  Rr261800, Rr268660, Rr273 ... (6 members)

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.
• J:328714: chr12:84523634-84564915 (mm10) chr12:84570408-84611689 (GRCm39)

• Genetic Map
  Chromosome 12, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  16 phenotypes from 3 alleles in 3 genetic backgrounds
  5 phenotype references
  

• All Mutations and Alleles
  3
• Endonuclease-mediated
  3
• Find Mice (IMSR)
  0 strains or lines available

Homozygous deletion of most of this Vsx2 super-enhancer results in absence of retina bipolar cells, thinner retina and reduced visual acuity or blindness.

References

• Summaries
  All 6

  Phenotypes 5
• Earliest
  J:282593 Norrie JL, et al., Nucleome Dynamics during Retinal Development. Neuron. 2019 Nov 6;104(3):512-528.e11
• Latest
  J:333875 Bian F, et al., Functional analysis of the Vsx2 super-enhancer uncovers distinct cis-regulatory circuits controlling Vsx2 expression during retinogenesis. Development. 2022 Aug 1;149(15):dev200642

Rr272 Cluster contains:

More Data for these features

Member	Feature Type	Location
Rr261800, regulatory region 261800	enhancer	Chr12:84599001-84599400 (.)
Rr268660, regulatory region 268660	enhancer	Chr12:84600401-84600600 (.)
Rr273, regulatory region 273	enhancer	Chr12, Syntenic
Rr274, regulatory region 274	enhancer	Chr12, Syntenic
Rr275, regulatory region 275	enhancer	Chr12, Syntenic
Rr276, regulatory region 276	enhancer	Chr12, Syntenic