Rr272 Other Genome Feature Detail

Summary

• Symbol
  Rr272
• Name
  regulatory region 272
• Synonyms
  Vsx2 CRC-SE, Vsx2-SE

• Feature Type
  enhancer
• IDs
  MGI:7339259
• Cluster Members
  Rr273, Rr274, Rr275 ... (6 members)

Location &
Maps

• Sequence Map
  Chr12:84570408-84611689 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI
• J:328714: chr12:84523634-84564915 (mm10) chr12:84570408-84611689 (GRCm39)

• Genetic Map
  Chromosome 12, Syntenic

Strain
Comparison

• SNPs within 2kb
  1173 from dbSNP Build 142

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  16 phenotypes from 3 alleles in 3 genetic backgrounds
  5 phenotype references
  

• All Mutations and Alleles
  3
• Endonuclease-mediated
  3
• Find Mice (IMSR)
  0 strains or lines available

Homozygous deletion of most of this Vsx2 super-enhancer results in absence of retina bipolar cells, thinner retina and reduced visual acuity or blindness.

References

• Summaries
  All 6

  Phenotypes 5
• Earliest
  J:282593 Norrie JL, et al., Nucleome Dynamics during Retinal Development. Neuron. 2019 Nov 6;104(3):512-528.e11
• Latest
  J:333875 Bian F, et al., Functional analysis of the Vsx2 super-enhancer uncovers distinct cis-regulatory circuits controlling Vsx2 expression during retinogenesis. Development. 2022 Aug 1;149(15):dev200642

Rr272 Cluster contains:

More Data for these features

Member	Feature Type	Location
Rr273, regulatory region 273	enhancer	Chr12:84578818-84579815
Rr274, regulatory region 274	enhancer	Chr12:84586536-84590457
Rr275, regulatory region 275	enhancer	Chr12:84592972-84597016
Rr276, regulatory region 276	enhancer	Chr12:84596238-84601716
Rr261800, regulatory region 261800	enhancer	Chr12:84599001-84599400 (.)
Rr268660, regulatory region 268660	enhancer	Chr12:84600401-84600600 (.)