Rr303 Other Genome Feature Detail

Summary

• Symbol
  Rr303
• Name
  regulatory region 303
• Synonyms
  ISE, Isl1-Locus-SAN-Enhancer

• Feature Type
  enhancer
• IDs
  MGI:7367201

Location &
Maps

• Sequence Map
  Chr13:116322276-116325052 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI
• range from start of 1st to end of 4th sgRNA: chr13:116322276-116325052 (GRCm39)

• Genetic Map
  Chromosome 13, Syntenic

Strain
Comparison

• SNPs within 2kb
  224 from dbSNP Build 142

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  7 phenotypes from 1 allele in 1 genetic background
  1 phenotype reference
  

• All Mutations and Alleles
  1
• Endonuclease-mediated
  1
• Find Mice (IMSR)
  0 strains or lines available

Deletion of this Isl1 sinoatrial node enhancer results in abnormal sinoatrial node and pacemaker cell morphology, reduced average heart rate and other cardiac anomalies.

References

• Summaries
  All 1

  Phenotypes 1
• Earliest
  J:308878 Galang G, et al., ATAC-Seq Reveals an Isl1 Enhancer That Regulates Sinoatrial Node Development and Function. Circ Res. 2020 Dec 4;127(12):1502-1518