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Rr303 Other Genome Feature Detail
Summary
  • Symbol
    Rr303
  • Name
    regulatory region 303
  • Synonyms
    ISE, Isl1-Locus-SAN-Enhancer
  • Feature Type
    enhancer
  • IDs
    MGI:7367201
Location &
Maps
more
  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • range from start of 1st to end of 4th sgRNA: chr13:116322276-116325052 (GRCm39)
  • Genetic Map
    Chromosome 13, Syntenic
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Deletion of this Isl1 sinoatrial node enhancer results in abnormal sinoatrial node and pacemaker cell morphology, reduced average heart rate and other cardiac anomalies.
References
more
  • Summaries
    All 1
    Phenotypes 1
  • Earliest
    J:308878 Galang G, et al., ATAC-Seq Reveals an Isl1 Enhancer That Regulates Sinoatrial Node Development and Function. Circ Res. 2020 Dec 4;127(12):1502-1518
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory