Rr314 Other Genome Feature Detail

Summary

• Symbol
  Rr314
• Name
  regulatory region 314
• Synonyms
  RE5

• Feature Type
  enhancer
• IDs
  MGI:7378759

Location &
Maps

• Sequence Map
  Chr11:94341417-94343002 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI
• chr11:94341417-94343002

• Genetic Map
  Chromosome 11, Syntenic

Strain
Comparison

• SNPs within 2kb
  133 from dbSNP Build 142

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  3 phenotypes from 1 allele in 1 genetic background
  1 phenotype reference
  

• All Mutations and Alleles
  2
• Endonuclease-mediated
  2
• Genomic Mutations
  1 involving Rr314
• Find Mice (IMSR)
  0 strains or lines available

Deletion of this cardiac Cacna1g and Epn3 enhancer leads to decreased heart rate, increased heart rate variability and abnormal sinoatrial node conduction.

References

• Summaries
  All 1

  Phenotypes 1
• Earliest
  J:295904 Mohan RA, et al., T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18617-18626