Tg(CAG-S100a16)#Gpt
Transgene Detail

Summary

• Symbol: Tg(CAG-S100a16)#Gpt
• Name: transgene insertion #, GemPharmatech Co., Ltd
• MGI ID: MGI:7398506
• Synonyms: S100a16^TG
• Transgene: Tg(CAG-S100a16)#Gpt Location: unknown
• Alliance: Tg(CAG-S100a16)#Gpt page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-S100a16)#Gpt expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	S100a16 (MGI:1915110)

• Tg(CAG-S100a16)#Gpt expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  chicken	CAG

• The CAG promoter drives ubiquitous expression of the mouse gene. (J:330793)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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tg1	Tg(CAG-S100a16)#Gpt/0	C57BL/6J-Tg(CAG-S100a16)#Gpt

Phenotypes:

Affected Systems	tg1
show or hide all annotated terms
homeostasis/metabolism	N
homeostasis/metabolism phenotype	N
liver/biliary system	√
liver fibrosis	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:330793 Zhang WS, et al., S100a16 deficiency prevents hepatic stellate cells activation and liver fibrosis via inhibiting CXCR4 expression. Metabolism. 2022 Jul 29;135:155271
• All: 3 reference(s)