Mirc55 Complex/Cluster/Region Detail

Summary

• Symbol
  Mirc55
• Name
  microRNA cluster 55, including Mir126a through Mir126b
• Synonyms
  Mir126

• Feature Type
  complex/cluster/region
• IDs
  MGI:7407146

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 2, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  17 phenotypes from 2 alleles in 2 genetic backgrounds
  17 phenotype references
  

• All Mutations and Alleles
  4
• Targeted
  4
• Find Mice (IMSR)
  2 strains or lines available

Mice homozygous for a null allele exhibit edema and hemorrhaging during embryogenesis, neonatal and postnatal lethality, reduced female fecundity, decreased vascular endothelial cell integrity, and increased susceptibility to myocardial infarction.

References

• Summaries
  All 18

  Phenotypes 17
• Earliest
  J:139708 Wang S, et al., The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell. 2008 Aug;15(2):261-71
• Latest
  J:330572 Guo FH, et al., Single-Cell Transcriptome Analysis Reveals Embryonic Endothelial Heterogeneity at Spatiotemporal Level and Multifunctions of MicroRNA-126 in Mice. Arterioscler Thromb Vasc Biol. 2022 Mar;42(3):326-342