Rr338 Other Genome Feature Detail

Summary

• Symbol
  Rr338
• Name
  regulatory region 338
• Synonyms
  TCE-7.1

• Feature Type
  enhancer
• IDs
  MGI:7413113

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.
• J:281897: chr2:9504884-9530005 (mm9) chr2:9588068-9613189 (GRCm39)

• Genetic Map
  Chromosome 2, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  3 phenotypes from 1 allele in 1 genetic background
  1 phenotype reference
  

• All Mutations and Alleles
  1
• Endonuclease-mediated
  1
• Find Mice (IMSR)
  0 strains or lines available

Deletion of this Gata3 enhancer disrupts early T lineage progenitor (ETP) and CD4 SP T cell development in thymus and CD4+ T cell numbers in spleen and peripheral blood.

References

• Summaries
  All 2

  Phenotypes 1
• Earliest
  J:281897 Hosoya-Ohmura S, et al., An NK and T cell enhancer lies 280 kilobase pairs 3' to the gata3 structural gene. Mol Cell Biol. 2011 May;31(9):1894-904
• Latest
  J:232438 Ohmura S, et al., Lineage-affiliated transcription factors bind the Gata3 Tce1 enhancer to mediate lineage-specific programs. J Clin Invest. 2016 Mar 1;126(3):865-78