Rr338 Other Genome Feature Detail

Summary

• Symbol
  Rr338
• Name
  regulatory region 338
• Synonyms
  Gata3 +278/285, TCE-7.1

• Feature Type
  enhancer
• IDs
  MGI:7413113
• Cluster Members
  Rr551574, Rr551576 (2 members)
• Regulates expression of
  Gata3 (1 regulated gene)

Location &
Maps

• Sequence Map
  Chr2:9588068-9613189 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI
• J:281897: chr2:9504884-9530005 (mm9) chr2:9588068-9613189 (GRCm39) chr2:9598300-9605582 (GRCm39) J:309550: chr2:9588068-9613189

• Genetic Map
  Chromosome 2, Syntenic

Strain
Comparison

• SNPs within 2kb
  673 from dbSNP Build 142

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  3 phenotypes from 1 allele in 1 genetic background
  2 phenotype references
  

• All Mutations and Alleles
  2
• Endonuclease-mediated
  2
• Find Mice (IMSR)
  0 strains or lines available

Deletion of this Gata3 enhancer disrupts early T lineage progenitor (ETP) and CD4 SP T cell development in thymus and CD4+ T cell numbers in spleen and peripheral blood.

References

• Summaries
  All 3

  Phenotypes 2
• Earliest
  J:281897 Hosoya-Ohmura S, et al., An NK and T cell enhancer lies 280 kilobase pairs 3' to the gata3 structural gene. Mol Cell Biol. 2011 May;31(9):1894-904
• Latest
  J:309550 Kasal DN, et al., A Gata3 enhancer necessary for ILC2 development and function. Proc Natl Acad Sci U S A. 2021 Aug 10;118(32):e2106311118

Rr338 regulates expression of:

Feature	Feature Type	Location	Reference
Gata3, GATA binding protein 3	protein coding gene	Chr2:9861889-9894845 (-)	J:281897

Rr338 Cluster contains:

More Data for these features

Member	Feature Type	Location
Rr551574, regulatory region 551574	enhancer	Chr2:9598674-9599000 (.)
Rr551576, regulatory region 551576	enhancer	Chr2:9600249-9600638 (.)