Rr386 Other Genome Feature Detail

Summary

• Symbol
  Rr386
• Name
  regulatory region 386
• Synonyms
  E4a

• Feature Type
  enhancer
• IDs
  MGI:7439573

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.
• primers chr6:124878980-124879003 (GRCm39) deletion chr6:124901815-124902199 (GRCm38) chr6:124878778-124879162 (GRCm39)

• Genetic Map
  Chromosome 6, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  3 phenotypes from multigenic genotypes
  1 phenotype reference
  

• All Mutations and Alleles
  1
• Endonuclease-mediated
  1
• Find Mice (IMSR)
  0 strains or lines available

Homozygous deletion of this effector helper T cell stimulus-responsive Cd4 enhancer affects Cd4 expression in peripheral and proliferating CD4+ T cells.

References

• Summaries
  All 1

  Phenotypes 1
• Earliest
  J:333574 Teghanemt A, et al., CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element. Nat Commun. 2022 Mar 18;13(1):1477